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The Colts–Patriots rivalry is a rivalry that is considered one of the most famous in the NFL.[2] The two teams combined for four Super Bowl victories (three by the Patriots) and seven AFC Championships since 2001, while both are noted for their organizational excellence.[2]
The nature of this rivalry is somewhat ironic because while the Colts and Patriots were AFC East division rivals from 1970–2001 (dating back to the Colts' time in Baltimore), their intensified enmity wasn't prevalent until Indianapolis was moved into the newly formed AFC South following the 2001 season as part of the NFL's realignment.[2] Since 2003, the rivalry has been bitterly close: following New England's 59-24 win in 2012 the Patriots lead the series with eight wins (two in the playoffs) versus five wins (one playoff) for the Colts, and the Patriots hold a lead in points scored, 368-329.
The modern matchup spanning the period of 1998–2013 was usually headlined as a contest between quarterbacks Peyton Manning and Tom Brady, who together won six NFL MVP awards in eight years (2003–10; four by Manning). In September 2001 Brady received his first start against the Colts after an injury to then-starter Drew Bledsoe, and proceeded to defeat the Colts in his first six games against them in the next years, including the 2003 AFC Championship Game and a 2004 AFC Divisional playoff game. The 2004 Divisional game was notable as the Patriots held a record breaking Colts offense to 3 points on snowy cold night in Foxborough. The Colts won the next three matches, notching two regular season victories and a win in the 2006 AFC Championship Game on the way to their win in Super Bowl XLI. Since then, the Patriots have won the four out of the next six games from 2007–12. The quarterback angle of the rivalry changed in 2012 with the surge to success of Colts rookie Andrew Luck.

The Patriots (12-4) earned a first-round bye with the No. 2 seed in the AFC. Unfortunately, the team wasn't able to get healthy during its time off considering inside linebacker Brandon Spikes was placed on injured reserve with a knee injury, as reported by the team's website. 

New England has been devastated by injuries all year long, but somehow, some way, Bill Belichick has managed to win games with the guys who have stayed healthy. 

The Colts reached the divisional round thanks to one of the most remarkable come-from-behind victories in the history of the playoffs. Andrew Luck led his team to a 45-44 win with a furious 35-point second-half flurry of offense, overcoming a 28-point deficit in the process.