Southampton will assess the fitness of club-record signing Dani Osvaldo before the New Year's Day encounter with Chelsea.
The Italy forward suffered a knock in the 1-1 draw at Newcastle and, having recovered from that, was then struck down by illness.
Morgan Schneiderlin returns from suspension while Nathaniel Clyne will be hoping to start as he steps up his return from a hamstring complaint. Artur Boruc, Victor Wanyama and Guly do Prado remain sidelined.
Chelsea, meanwhile, are without Frank Lampard, Branislav Ivanovic and David Luiz.
Lampard and Ivanovic were injured in Sunday's win over Liverpool, when Luiz picked up his fifth booking of the season to incur a suspension.
Ivanovic's injury means Ashley Cole is set to return at left-back with Cesar Azpilicueta switching to the right, while midfielder Ramires is back from a one-game ban.